Median preoptic area neurons are required for the cooling and febrile activations of brown adipose tissue thermogenesis in rat
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چکیده
منابع مشابه
Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits.
Brown adipose tissue (BAT) thermogenesis is critical to maintain homoeothermia and is centrally controlled via sympathetic outputs. Body temperature and BAT activity also impact energy expenditure, and obesity is commonly associated with decreased BAT capacity and sympathetic tone. Severely obese mice that lack leptin or its receptor (LepRb) show decreased BAT capacity, sympathetic tone, and bo...
متن کاملBrown adipose tissue and thermogenesis.
The growing understanding of adipose tissue as an important endocrine organ with multiple metabolic functions has directed the attention to the (patho)physiology of distinct fat depots. Brown adipose tissue (BAT), in contrast to bona fide white fat, can dissipate significant amounts of chemical energy through uncoupled respiration and heat production (thermogenesis). This process is mediated by...
متن کاملMechanisms of thermogenesis in brown adipose tissue.
In 1969, Rafael and colleagues observed that the uncoupled state of mitochondria prepared from the brown fat of newborn guinea pigs could be reversed by incubation in the presence of albumin and certain purine nucleotides (Rafael et al., 1969). In 1974, we showed that this uncoupled state was due to the presence in the inner membrane of the mitochondria of a regulatable ion conductance pathway,...
متن کاملBrown adipose tissue thermogenesis in obese animals.
(Hales, J. R. S., eds.), pp. 169-173, Raven Press, New York Nedergaard, J., Alexson, S. & Cannon, B. (1980) Am. J . Physiol. 239, C208Z2 16 Nedergaard, J., Connolly, E., NBnberg, E. & Mohell, N. (1984) Biochem. Soc. Trans. 12, 393-396 Nedergaard, J., Connolly, E. & Cannon, B. (1986) in Brown Adipose Tissue (Trayhurn, P. & Nicholls, D. G., eds.), Edward Arnold, London, in the press Raasmaja, A.,...
متن کاملCentral Control of Brown Adipose Tissue Thermogenesis
Thermogenesis, the production of heat energy, is an essential component of the homeostatic repertoire to maintain body temperature during the challenge of low environmental temperature and plays a key role in elevating body temperature during the febrile response to infection. Mitochondrial oxidation in brown adipose tissue (BAT) is a significant source of neurally regulated metabolic heat prod...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-74272-w